ReeVeda

Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans , widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.

It is Sulfated glycosaminoglycan (GAG). It is found naturally in the body. It’s a vital part of joint cartilage and gives cartilage elasticity by helping it retain water. It is important in maintaining the structural integrity of the tissue.

Source:

An amino sugar derived from cartilage of cows, pigs, and sharks.

Dosage:

1200mg /day. According to PDR studies, it is recommended dose for Osteoarthritis.

Structure:

Chondroitin sulfate is a sulfated glycosaminoglycan (GAG) composed of a chain of alternating sugars (N-acetylgalactosamine and glucuronic acid).

It is usually found attached to proteins as part of a proteoglycan. A chondroitin chain can have over 100 individual sugars, each of which can be sulfated in variable positions and quantities.

Chondroitin sulfate chains are unbranched polysaccharides of variable length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).

Mechanism of Action:

The polysaccarides in the proteoglycan are called glycosaminoglycans.

Chondritin sulphate & hyaluronic acid are vital for the structure and function of articular cartilage chondroitin sulphate & hyaluronic acid are building blocks of aggrecan (Aggrecan is cartilage-specific proteoglycan core protein) found in articular cartilage. It has shock absorbing properties. It does this by providing cartilage with a swelling pressure that is restrained by tensile force of collagen fiber. This balance confers upon articular cartilage the deformable resilience vital to its function.

Safety Concerns:

Chondroitin sulfate is likely safe for most people. It can cause some mild stomach pain and nausea. Other side effects that have been reported are diarrhea, constipation, swollen eyelids, leg swelling, hair loss, and irregular heartbeat.

Asthma: There is some concern that chondroitin sulfate might make asthma worse. If you have asthma, there are no known interactions with herbs and supplements.

There are no known interactions with foods.

Absorption:

Chondroitin sulfates is absorbed in digestive tract & uptake in tissue and excretion in urine.

Distribution:

significantly high activity was detected in kidneys and liver as well as the gastro-intestinal tract. This distribution is within organs.

Role:

• Chondroitin sulphate is a vital part of joint cartilage and gives cartilage elasticity by helping it retain water.
• Important in maintaining the structural integrity of the tissue.
• It is prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.
• Reducing pain from a type of arthritis called osteoarthritis, when taken by mouth. In osteoarthritis, the cartilage in the joints breaks down. Chondroitin sulfate is one of the building blocks of cartilage might slow this breakdown.