Curcumin (diferuloylmethane) is a yellow component of turmeric (Curcuma longa).It is estimated that every 100 g of Turmeric contains 3-5 g of Curcumin.
400 mg to 600 mg per day.
ICurcumin incorporates several functional groups. The aromatic rings, which are polyphenols are connected by two α,β-unsaturated carbonyl groups.
Mechanism of Action:
The anti inflammatory activity of cuminoids is because of several mechanism including inhibition of cyclo-oxygenase (COX) and Lypo-oxygenase(LOX), reduction of the release of ROS (Reactive Oxygen Species) by stimulated Nutrophilis, inhibition of AP-1, and NF-KappaB and inhibition of activation of proinflametory cytokines TNF (Tumor necrosis factor) alpha & IL 1β.
Curcumin is generally considered safe for consumption.
Curcumin is poorly absorbed if given directly. Absorption appears to be better with food.
The metabolites majorly formed in liver are glucoronoside, dihydrocurcumin glucuronoside, tetrahydrocurcumin glucuroniside & tetrahydrocurcumin.
- Suppresses Arthritis Symptoms and well known for its anti-inflammatory properties.
- Reduces damage to bone and cartilage and relieves morning stiffness and joint swelling, and improved walking time.
- Curcumin has worked as well for rheumatoid arthritis, osteoarthritis and post-operative inflammation.
- Curcumin has the potential to treat a wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer's disease, psoriasis, etc, through modulation of numerous molecular targets.
- These include its anti inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antiprotozoal, antiviral, antifibrotic, antivenomic, antiulcer, hypotensive and hypocholesteremic activities.
- It has anti-inflammatory activity is actually due to the active ingredient, Curcumin.
- Curcumin works by inhibiting the activity and synthesis of the enzymes implicated in inflammation. In addition, its activity can modulate up to 700 genes. It is a natural detoxifier, anti-amyloid and antioxidant.