ReeVeda

Source:

Curcumin (diferuloylmethane) is a yellow component of turmeric (Curcuma longa).It is estimated that every 100 g of Turmeric contains 3-5 g of Curcumin.

Dosage:

400 mg to 600 mg per day.

Structure:

ICurcumin incorporates several functional groups. The aromatic rings, which are polyphenols are connected by two α,β-unsaturated carbonyl groups.

Other name:

curcumin, diferuloylmethane.

Mechanism of Action:

The anti inflammatory activity of cuminoids is because of several mechanism including inhibition of cyclo-oxygenase (COX) and Lypo-oxygenase(LOX), reduction of the release of ROS (Reactive Oxygen Species) by stimulated Nutrophilis, inhibition of AP-1, and NF-KappaB and inhibition of activation of proinflametory cytokines TNF (Tumor necrosis factor) alpha & IL 1β.

Side Effects:

Curcumin is generally considered safe for consumption.

Metabolism:

Curcumin is poorly absorbed if given directly. Absorption appears to be better with food.

The metabolites majorly formed in liver are glucoronoside, dihydrocurcumin glucuronoside, tetrahydrocurcumin glucuroniside & tetrahydrocurcumin.

Role:

• Suppresses Arthritis Symptoms and well known for its anti-inflammatory properties.
• Reduces damage to bone and cartilage and relieves morning stiffness and joint swelling, and improved walking time.
• Curcumin has worked as well for rheumatoid arthritis, osteoarthritis and post-operative inflammation.
• Curcumin has the potential to treat a wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer's disease, psoriasis, etc, through modulation of numerous molecular targets.
• These include its anti inflammatory, antioxidant, anticarcinogenic, antimutagenic, anticoagulant, antiprotozoal, antiviral, antifibrotic, antivenomic, antiulcer, hypotensive and hypocholesteremic activities.
• It has anti-inflammatory activity is actually due to the active ingredient, Curcumin.
• Curcumin works by inhibiting the activity and synthesis of the enzymes implicated in inflammation. In addition, its activity can modulate up to 700 genes. It is a natural detoxifier, anti-amyloid and antioxidant.