Glucosamine is an amino sugar, is thought to promote the formation and repair of cartilage.It is found naturally in Animal body.
Amino sugar derived from shellfish or prepared in the laboratory.
1500mg/day.There is no Dietary Reference Intake (DRI) established.According to studies,it is the recommended dose for Osteoarthritis.
Mechanism of Action:
The glucosamine contains glycosaminoglycan (GAG), which is vital for the function of articular cartilage.
GAG chains are building blocks of aggrecan (Aggrecan is cartilage-specific proteoglycan core protein) found in articular cartilage.
Agreecan shows articular cartilage shock absorbing properties. It does this by providing cartilage with a swelling pressure that is restrained by the tensile forces of collagen fibers.
90% of glucosamine administered totally as a glucosamine salt gets absorbed from the small intestine & from there it is transported via portal circulation to the liver. It appears that a significant fraction of the ingested glucosamine is catabolised by first pass metabolism in the liver.
nausea, vomiting may occur.
It plays an important role in the synthesis of glycosaminoglycans and glycoproteins (the building blocks of many structures of the joints, including the ligaments, tendons, cartilage and the synovial fluid.)
- Administration of glucosamine rebuilds cartilage as well as delays its degradation.
- Glucosamine is more effective than selected non-steroidal anti-inflammatory drugs in reducing pain in patients with osteoarthritis.
- Glucosamine regulates cartilage turnover in patients of osteoarthritis.